Cefixime and azithromycin tablets dose


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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 400mg

tablet, chewable

  • 100mg
  • 200mg

oral suspension

  • 100mg/5mL
  • 200mg/5mL
  • 500mg/5mL

more...

Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis

400 mg/day PO in single daily dose or divided q12hr

Otitis Media

400 mg/day PO in single daily dose or divided q12hr

Pharyngitis/Tonsillitis

400 mg/day PO in single daily dose or divided q12hr

Uncomplicated Gonorrhea

Alternative treatment of uncomplicated urogenital, anorectal, or pharyngeal gonorrhea if ceftriaxone unavailable; no longer indicated as first-line treatment, per CDC guidelines

400 mg PO once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days

CDC STD guidelines: MMWR Recomm Rep. June 5, 2015:64(RR3);1-137

Uncomplicated Urinary Tract Infections

400 mg/day PO in single daily dose or divided q12hr

Typhoid Fever (Off-label)

15-20 mg/kg/day PO divided q12hr for 7-14 days

Dosing Modifications

Renal impairment

  • CrCl >60 mL/min: Dosage adjustment not necessary
  • CrCl 21-60 mL/min: 260 mg/day PO
  • CrCl <20 mL/min: 200 mg/day PO

Dosing Considerations

Susceptible organisms

  • Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Proteus mirabilis, Streptococcus pneumoniae, Streptococcus pyogenes, Enterobacteriaceae, Salmonella spp, Serratia spp, Shigella spp

Dosage Forms & Strengths

tablet

  • 400mg

tablet, chewable

  • 100mg
  • 200mg

oral suspension

  • 100mg/5mL
  • 200mg/5mL
  • 500mg/5mL

more...

Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis

<6 months: Safety and efficacy not established

6 months-12 years, ≤50 kg: 8 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 400 mg/day 

>12 years: 400 mg/day PO in single daily dose or divided q12hr

Otitis Media

<6 months: Safety and efficacy not established

6 months-12 years, ≤50 kg: 8 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 400 mg/day 

>12 years: 400 mg/day PO in single daily dose or divided q12hr

Pharyngitis/Tonsillitis

<6 months: Safety and efficacy not established

6 months-12 years, ≤50 kg: 8 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 400 mg/day 

>12 years: 400 mg/day PO in single daily dose or divided q12hr

Uncomplicated Gonorrhea

Cervical or urethral gonorrhea

<6 months: Safety and efficacy not established

6 months-12 years, ≤50 kg: 8 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 400 mg/day 

>12 years: 400 mg PO once plus azithromycin 1 g in single dose or doxycycline 100 mg PO q12hr for 7 days

Uncomplicated Urinary Tract Infections

<6 months: Safety and efficacy not established

6 months-12 years, ≤50 kg: 8 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 400 mg/day 

>12 years: 400 mg/day PO in single daily dose or divided q12hr

Typhoid Fever (Off-label)

15-20 mg/kg/day PO divided q12hr for 7-14 days; not to exceed 400 mg/day

Interactions

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Adverse Effects

>10%

Diarrhea (16%)

Frequency Not Defined

Abdominal pain

Candidiasis

Dizziness

Dyspepsia

Elevated transaminases

Eosinophilia

Erythema multiforme

Fever

Flatulence

Headache

Increased blood urea nitrogen (BUN)

Increased creatinine

Leukopenia

Nausea

Prolonged prothrombin time (PT)

Pruritus

Pseudomembranous colitis

Rash

Serum sickness-like reaction

Stevens-Johnson syndrome

Thrombocytopenia

Urticaria

Vaginitis

Vomiting

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Warnings

Contraindications

Documented hypersensitivity

Cautions

Limited activity against anaerobes

Dosage must be adjusted in severe renal insufficiency (high doses may cause CNS toxicity); superinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy

Use with caution in patients with history of penicillin allergy

Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy

Phenylalanine can be harmful to patients with phenylketonuria (PKU); chewable tablets contain aspartame, a source of phenylalanine; before prescribing, consider combined daily amount of phenylalanine from all sources, including chewable tablets

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Pregnancy & Lactation

Pregnancy category: B

Lactation: Unknown whether drug is excreted in milk

Pregnancy Categories

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Pharmacology

Mechanism of Action

Third-generation oral cephalosporin with broad activity against gram-negative bacteria; by binding to 1 or more penicillin-binding proteins, it arrests bacterial cell-wall synthesis and inhibits bacterial growth

Absorption

Bioavailability: 40-50%

Distribution

Distributed widely throughout body and reaches therapeutic concentration in most tissues and body fluids, including synovial, pericardial, pleural, and peritoneal; bile, sputum, and urine; bone, myocardium, gallbladder, skin, and soft tissue

Protein bound: 65%

Elimination

Half-life: 3-4 hr

Excretion: Urine (50% as unchanged drug), feces (10%)

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Patient Handout

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Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier Description
tablets 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Plans
Non-Medicare Plans Medicare Plans

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Source: http://reference.medscape.com/drug/suprax-cefixime-342503


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Дата: 06.09.2017, 02:21 / Просмотров: 71431